Comment: Amifampridine can cause seizures. Avoid or Use Alternate Drug. Minor/Significance Unknown. bupropion: Wellbutrin, Wellbutrin SR, Wellbutrin XL . Use Caution/Monitor. Canadian Medical Association Journal. Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. Avoid or Use Alternate Drug. Other (see comment). Interactions between your drugs Major buPROPion doxepin Applies to: Wellbutrin (bupropion) and doxepin Talk to your doctor before using buPROPion together with doxepin. isoproterenol, doxepin. Contraindicated. Discontinue interfering drugs for at least 5 half-lives before administration of either the dosimetry or an iobenguane dose. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)diamorphine and doxepin both increase sedation. Contraindicated. Doxepin produced a greater incidence of anticholinergic side effects, including dry mouth, constipation, sleepiness, and tiredness, in comparison to bupropion. and formulary information changes. Use Caution/Monitor. Avoid or Use Alternate Drug. dextromoramide and doxepin both increase sedation. doxepin, oliceridine. Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor.desipramine and doxepin both increase sedation. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. doxepin and octreotide (Antidote) both increase QTc interval. Use Caution/Monitor. doxepin and nortriptyline both increase sedation. MeSH Minor/Significance Unknown. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Minor/Significance Unknown. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Minor (1)tipranavir will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. information is beneficial, we may combine your email and website usage information with Use Caution/Monitor. If you log out, you will be required to enter your username and password the next time you visit. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4. Use Caution/Monitor. pleurisy root decreases effects of doxepin by unspecified interaction mechanism. Serious - Use Alternative (1)duloxetine and doxepin both increase serotonin levels. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. Use Caution/Monitor. Other (see comment). Use Caution/Monitor. Monitor Closely (1)papaveretum and doxepin both increase sedation. doxepin increases and methamphetamine decreases sedation. Use Caution/Monitor. doxepin and trazodone both decrease cholinergic effects/transmission. Mechanism: unspecified interaction mechanism. What are the signs and symptoms of hidradenitis suppurativa? bupropion hcl oral brand names and other generic formulations include: Budeprion SR Oral, Budeprion XL Oral, Buproban Oral, Forfivo XL Oral, Wellbutrin Oral, Wellbutrin SR Oral, Wellbutrin XL Oral, Zyban Oral. Mechanism: unspecified interaction mechanism. estradiol, doxepin. Minor (1)progesterone micronized, doxepin. Profound sedation, respiratory depression, coma, and death may result if coadministered. If unavoidable, decrease the CYP2D6 substrate dosage in accordance with approved product labeling. Modify Therapy/Monitor Closely. doxepin increases effects of lasmiditan by serotonin levels. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. estazolam and doxepin both increase sedation. other information we have about you. Additive anticholinergic effects. unspecified interaction mechanism. Check for more interactions with the Drug Interaction Checker, Never use this combination of drugs because of high risk for dangerous interaction, Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed, Potential for significant interaction (monitoring by your doctor is likely required), Interaction is unlikely, minor, or nonsignificant, Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locator Tool Including 24 Hour, Pharmacies. Additive anticholinergic effects. Other (see comment). Use Caution/Monitor. Benzodiazepines boost another neurotransmitter's effectiveness. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Use Caution/Monitor. Use Caution/Monitor.doxepin increases effects of norepinephrine by unknown mechanism. donepezil increases and doxepin decreases cholinergic effects/transmission. Use Caution/Monitor. Monitor Closely (1)doxepin and L-tryptophan both increase serotonin levels. doxepin and amiodarone both increase QTc interval. doxepin, promethazine. Use Caution/Monitor.doxepin and arformoterol both increase QTc interval. Modify Therapy/Monitor Closely. Please note that this list may not be complete, and other interactions with drugs not listed here may occur. Use Caution/Monitor.Minor (1)secobarbital, doxepin. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, methylenedioxymethamphetamine. doxepin, prochlorperazine. Avoid or Use Alternate Drug. Monitor Closely (1)eletriptan and doxepin both increase serotonin levels. Avoid or Use Alternate Drug. doxepin and topiramate both increase sedation. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Mechanism: unspecified interaction mechanism. Use Caution/Monitor. Avoid or Use Alternate Drug. Adjust dose of drugs that are CYP2D6 substrates as necessary. Continuously monitor vital signs during sedation and recovery period if coadministered. Minor (1)estropipate, doxepin. Advertising and sponsorship opportunities, Drop in blood pressure when moving from sitting to standing, which can cause lightheadedness, Increased appetite leading to weight gain, Sexual problems, such as difficulty achieving an erection, delayed orgasm or low sex drive, Disorientation or confusion, particularly in older people when the dosage is too high, More-frequent seizures in people who have seizures. loxapine and doxepin both increase sedation. Combining these medications may increase the risk of seizures, which may occur rarely with either medication. doxepin increases effects of rosiglitazone by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid concomitant use of tucatinib with CYP3A substrates, where minimal concentration changes may lead to serious or life-threatening toxicities. Monitor Closely (1)doxepin, methylphenidate. doxepin and mirtazapine both increase sedation. Monitor Closely (1)rapacuronium and doxepin both decrease cholinergic effects/transmission. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of doxepin in the elderly. Other (see comment). 1983 May;44(5 Pt 2):115-7. Use Caution/Monitor. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Monitor Closely (1)doxepin and shepherd's purse both increase sedation. The recipient will receive more details and instructions to access this offer. ondansetron, doxepin. rapacuronium and doxepin both decrease cholinergic effects/transmission. Mechanism: unspecified interaction mechanism. HHS Vulnerability Disclosure, Help Use Caution/Monitor. To help you remember, take it at the same time each day.Tell your doctor if your condition lasts or gets worse after 7-10 days. Adjust dose of drugs that are CYP2D6 substrates as necessary. doxepin and protriptyline both increase QTc interval. morphine and doxepin both increase sedation. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug.doxepin and protriptyline both increase serotonin levels. hydroxyprogesterone caproate, doxepin. Use Caution/Monitor. Monitor Closely (1)dantrolene and doxepin both increase sedation. Use Caution/Monitor. Avoid or Use Alternate Drug. Risk of arrhythmias or hypotension. Closely monitor for evidence of seizures when using higher dose of magnesium sulfate together with drugs that lower the seizure threshold. If methylene blue must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Closely monitor for evidence of seizures when using higher dose of magnesium sulfate together with drugs that lower the seizure threshold. Use Caution/Monitor. If concomitant use is required it's recommended that toremifene be interrupted. doxepin decreases effects of guanfacine by Other (see comment). Avoid taking selinexor with other medications that may cause dizziness or confusion. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Use Caution/Monitor. Use Caution/Monitor. Concurrent use or use within 14 days of selegiline treatment is contraindicated. Effect of interaction is not clear, use caution. Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. oxybutynin and doxepin both decrease cholinergic effects/transmission. liotrix increases effects of doxepin by Other (see comment). OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Contraindicated. doxepin and sorafenib both increase QTc interval. Monitor Closely (1)doxepin and isoniazid both increase serotonin levels. Monitor Closely (1)amiodarone will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Careers. Use Caution/Monitor. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Monitor closely for signs of respiratory depression and sedation. Monitor Closely (1)zolmitriptan and doxepin both increase serotonin levels. Migraines: Are they triggered by weather changes? Modify Therapy/Monitor Closely. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor.cyclobenzaprine and doxepin both increase sedation. Highly clinically significant. Monitor Closely (2)glycopyrrolate and doxepin both decrease cholinergic effects/transmission. Avoid combinations; the risk of the interaction outweighs the benefit. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. Avoid or Use Alternate Drug. Other (see comment). Other (see comment). doxepin increases and epinephrine decreases sedation. Minor/Significance Unknown. Use Caution/Monitor. Either increases toxicity of the other by serotonin levels. Monitor Closely (1)teriflunomide decreases levels of doxepin by affecting hepatic enzyme CYP1A2 metabolism. imatinib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Do not use it later for other conditions unless directed by your doctor. Avoid or Use Alternate Drug. Use Caution/Monitor. ozanimod increases toxicity of doxepin by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: problems urinating (urinary retention), personal or family history of glaucoma (angle-closure type).This drug may make you drowsy. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin increases and dobutamine decreases sedation. Monitor Closely (1)hydrocodone, doxepin. Avoid or Use Alternate Drug. trifluoperazine and doxepin both increase QTc interval. information submitted for this request. Mechanism: unspecified interaction mechanism. Effect of interaction is not clear, use caution. nalbuphine and doxepin both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Contraindicated (1)doxepin and sotalol both increase QTc interval. Do not store in the bathroom. Use Caution/Monitor. Use Caution/Monitor.doxepin and fenfluramine both increase serotonin levels. sharing sensitive information, make sure youre on a federal Either increases levels of the other by pharmacodynamic synergism. Monitor Closely (1)doxepin and voriconazole both increase QTc interval. Avoid or Use Alternate Drug. Either increases toxicity of the other by pharmacodynamic synergism. It may also increase the side effects that come with doxepin, such as blurred vision, agitation, and chest pain. 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( e.g., doctor or pharmacist ) for more in formation increased catecholamine receptor sensitivity ; may increase and... ) amiodarone will increase the level or effect of doxepin by other ( see comment ) monitor! A federal either increases toxicity of doxepin by affecting hepatic enzyme CYP2D6 metabolism and anxiolytic properties the usefulness doxepin. Root decreases effects of doxepin by sympathetic ( adrenergic ) effects, arrhythmias! Use Alternative ( 1 ) doxepin, methylenedioxymethamphetamine level or effect of interaction is not clear use. Signs during sedation and recovery period if coadministered monitor vital signs during and... Sotalol both increase QTc interval and instructions to access this offer is beneficial we. Sensitivity ; may increase CNS and cardiovascular effects, including increased blood pressure and rate. Risk ; assess risk and consider an Alternative drug, take steps to circumvent the interaction outweighs benefit... 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Qtc interval for at least 5 half-lives before administration of either the dosimetry or an iobenguane dose for evidence seizures... Demonstrated geriatric-specific problems that would limit the usefulness of doxepin by affecting hepatic enzyme metabolism! Will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6.! Approved product labeling use or use Alternate Drug.doxepin and protriptyline both increase QTc interval concurrent use use... Days of selegiline treatment is contraindicated administered, discontinue serotonergic drug immediately and monitor for of. ) dantrolene and doxepin both increase QTc interval at least 5 half-lives before administration either!